Prematurity is a risk factor of disorders of gut-brain interaction in adults: A case-control study

Table 3 Prevalence of disorders of gut-brain interaction

Population results	Cases (n)	Percentage (%)	Controls (n)	Percentage (%)	P value
Number	79		124
Sex	F: 55/M: 24	70/30	F: 64/M: 60	52/48	0.02
Sex ratio (M/F)	0.4		0.9
Age (year)	27 (24; 29)		33 (27; 50)		< 0.001
Age range	18-32		20-76
% (18-32 years old)	79	100	59	48
A: Esophageal disorders	5	6	12	10	0.56
B: Gastroduodenal disorders	23	29	21	17	0.06
B1a: Postprandial distress syndrome	10	13	8	7	0.21
B1b: Epigastric pain syndrome	6	8	6	5	0.61
C: Bowel disorders	40	51	40	32	0.01
C1: Irritable bowel syndrome	12	15	11	9	0.25
C2: Functional constipation	20	25	10	8	0.002
C3: Functional diarrhea	7	9	7	6	0.55
D: Centrally mediated disorders of gastrointestinal pain	0	0	0	0	Not applicable
E: Gallbladder and sphincter of Oddi disorders	0	0	1	1	1
F: Anorectal disorders	3	4	12	10	0.2
At least one DGBI	45	57	62	50	0.41
At least 1 pain-related DGBI1	15	19	24	19	1

¹Pain-related disorders of gut-brain interaction; are defined as functional chest pain, functional heartburn, reflux hypersensitivity, epigastric pain syndrome, irritable bowel syndrome, abdominal pain subclass of unspecified functional bowel disorder, centrally mediated abdominal pain syndrome, biliary pain, levator ani syndrome, unspecified functional anorectal pain and proctalgia fugax.

DGBI: Disorders of gut-brain interaction; F: Female; M: Male.