Uveitis associated with juvenile idiopathic arthritis and chronic idiopathic uveitis in children: A retrospective cohort study

Table 3 Comparative analysis of uveitis cohort stratified by human leukocyte antigen-B27 status

Parameter	HLA-B27 (+) (n = 23)	HLA-B27 (-) (n = 49)	P value
Males	5 (21.7)	22 (44.9)	0.071
Age at diagnosis of uveitis (years)			0.606
Mean	8.6	8.4
Median (25%, 75%)	6.3 (4.8, 13.1)	8.3 (6.2, 10.1)
Min–max	1.9–17.7	3.2–14.9
Age at diagnosis of arthritis (years)			0.167
Mean	9.3	7.4
Median (25%, 75%)	8.9 (5.9, 13.2)	7.0 (3.5, 10.9)
Min–max	1.3-16.2	1.0–15.4
Anatomical type of uveitis			0.385
Anterior	16 (69.6)	26 (53.1)
Pars planitis	1 (4.3)	5 (10.2)
Posterior	0 (0.0)	5 (10.2)
Panuveitis	6 (26.1)	13 (26.5)
Manifested (“red-eye”) uveitis	15 (65.2)	13 (26.5)	0.004
Unilateral uveitis	17 (73.9)	17 (34.7)	0.002
Eye complications at first examination	7 (30.4)	14 (28.6)	1.0
Antinuclear antibodies positivity	7/20 (35.0)	21/47 (44.7)	0.591
Uveitis appearance			0.795
Before arthritis	6 (26.1)	10 (20.4)
Simultaneously with arthritis	4 (17.4)	5 (10.2)
After arthritis	8 (34.8)	17 (34.7)
Unknown	0 (0.0)	1 (2.0)
Chronic idiopathic uveitis	5 (21.7)	16 (32.7)
C-reactive protein (mg/L)			0.893
Mean	7.4	22.2
Median (25%, 75%)	1.0 (1.0, 8.9)	1.0 (0.6, 11.9)
Min–max	1.0–30.0	0.0–133.0
ESR (mm/hour)			0.132
Mean	28.9	21.6
Median (25%, 75%)	24.0 (20.0, 39.0)	15.0 (8.0, 25.0)
Min–max	8.0-56.0	2.0–77.0
Active joint at onset			0.344
Mean	1.5	2.0
Median (25%, 75%)	1.0 (1.0, 2.0)	1 (1.0, 3.0)
Min–max	1.0–3.0	1.0–5.0

Data are presented as n (%). HLA-B27: Human leukocyte antigen-B27; Max: Maximum; Min: Minimum.