Brain metabolic profile assessed by magnetic resonance spectroscopy in ‎‎children with Down syndrome: Relation to intelligence quotient

doi:10.5409/wjcp.v12.i5.310

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World Journal of Clinical Pediatrics

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2219-2808

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Clin Pediatr. Dec 9, 2023; 12(5): 310-318
Published online Dec 9, 2023. doi: 10.5409/wjcp.v12.i5.310

Table 3 Correlation between intelligence quotient and the brain metabolite ratios in children with down syndrome

Correlations with IQ	r	P value
F NAA/Cr	0.533	< 0.001¹
F Cho/Cr	-0.210	0.193
F MI/Cr	-0.259	0.107
T NAA/Cr	0.215	0.182
T Cho/Cr	0.330	0.037
T MI/Cr	-0.018	0.913
BG NAA/Cr	0.100	0.541
BG Cho/Cr	0.105	0.518
BG MI/Cr	0.008	0.961
O NAA/Cr	0.091	0.578
O Cho/Cr	-0.346	0.029
O MI/Cr	0.215	0.184

¹P < 0.01 is significant.

BG: Basal ganglia; Cho: Choline; Cr: Creatine; DS: Down syndrome; F: Frontal; IQ: Intelligence quotient; MI: Myoinositol; NAA: N-acetyl aspartate; O: Occipital; T: Temporal.

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Citation: El Feil NS, Elmahdy HS, Elmahdy RA, Aboelezz‎ AAE, Dawoud HS, Al-Beltagi M. Brain metabolic profile assessed by magnetic resonance spectroscopy in ‎‎children with Down syndrome: Relation to intelligence quotient. World J Clin Pediatr 2023; 12(5): 310-318
URL: https://www.wjgnet.com/2219-2808/full/v12/i5/310.htm
DOI: https://dx.doi.org/10.5409/wjcp.v12.i5.310

El Feil NS, Elmahdy HS, Elmahdy RA, Aboelezz‎ AAE, Dawoud HS, Al-Beltagi M. Brain metabolic profile assessed by magnetic resonance spectroscopy in ‎‎children with Down syndrome: Relation to intelligence quotient. World J Clin Pediatr 2023; 12(5): 310-318 [PMID: 38178937 DOI: 10.5409/wjcp.v12.i5.310]

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