Autotaxin and lysophosphatidic acid signalling in lung pathophysiology

Table 1 Expression of lysophosphatidic acid receptor in pulmonary cell types and leukocytes

Cell type	LPAR1	LPAR2	LPAR3	LPAR4	LPAR5	LPAR6	Ref.
NHBEs	+++	++	+++	-	+	+	[41]
NHBEs	+++	++	+++	-	++	+	[59]
NHBEs	++	++	++	-	NA	NA	[43]
HBE	++	++	NA	NA	NA	NA	[56]
HBE (BEAS-2B)	++	++	++	+	++	+	[59]
HBE (HBEpCs)	+++	+	++	+	+	NA	[209]
HBE (HBEpCs)	++	++	++	NA	NA	NA	[46]
HBE (HBEpCs)	++	++	++	NA	NA	NA	[49]
HBE (HBEpCs)	++	++	++	NA	NA	NA	[68]
Primary mouse tracheal EpCs	++	+++	++	++	-	NA	[57]
NHBE cells	++	++	++	-	NA	NA	[43]
A549 alveolar epithelial carcinoma	++	NA	NA	NA	NA	NA	[40]
A549 alveolar epithelial carcinoma	+++	+	-	-	NA	NA	[74]
NCI-H522 lung epithelial carcinoma	-	++	+	-	NA	NA	[74]
RLCNR rat lung adenocarcinoma	NA	NA	-	NA	++	NA	[283]
Primary mouse lung fibroblasts	+++	+	+	+	++	NA	[31]
human fetal lung fibroblasts MRC5	+++	++	++	+	+	NA	[226]
Mouse embryonic fibroblasts	+++	++	+	+++	+	NA	[101]
NHLFs CCL-151	+++	+	++	+	+	++	[81]
NHLFs	++	++	NA	NA	NA	NA	[42]
Primary mouse lung endothelial	++	+	-	+++	+	NA	[31]
HPAECs	+	++	+	+	+	+++	[106]
HMVECs	+	++	+	+	+	+++	[106]
HEV ECs	NA	NA	NA	++	NA	++	[116]
Human eosinophils	+	-	+	NA	NA	NA	[148]
Primary mouse neutrophils	-	+++	-	-	+	NA	[31]
Primary mouse alveolar macrophages	-	+	+	+	+	NA	[31]
Human alveolar macrophages	+	++	++	NA	NA	NA	[158]
Rat alveolar macrophages	++	+	-	NA	NA	NA	[158]
Human monocytes	+	-	-	NA	NA	NA	[176]
Mouse DCs	++	++	++	NA	NA	NA	[58]
Human immature DCs	+	+	+	NA	NA	NA	[172]
Human mature DCs	+	+	+	NA	NA	NA	[172]
Human immature DCs	-	+	-	NA	NA	NA	[174]
Human mature DCs	-	+	-	NA	NA	NA	[174]
Mouse immature DCs	++	+	+++	++	+++	NA	[175]
Mouse mature DCs	+++	+	+	++	++	NA	[175]
Jurkat T cells	+	+++	-	NA	NA	NA	[178]
Jurkat T cells	+	+	+	NA	NA	NA	[295]
Human CD4 T cells	+	+++	NA	NA	NA	NA	[177]
Human CD4 T cells	+	+++	-	NA	NA	NA	[176]
Human CD8 T cells	-	-	-	NA	NA	NA	[176]
Mouse CD4 T cells	+	+	+	+	+	NA	[31]
Mouse CD8 T cells	+	+++	+	+	++	NA	[31]
Human B lymphocytes	-	+	+	NA	NA	NA	[176]
Human platelets	+	NA	+	NA	NA	NA	[296]
Human platelets	+	+	+	NA	NA	NA	[295]
Human platelets	+	+	+	+	+	NA	[297]
Human mast cells	+	+	+	+	NA	NA	[199]
Human mast cells	+	+	+	-	NA	NA	[200]
Human mast cells	-	++	+	-	+++	++	[201]
Lung resident mesenchymal stem cells	+++	+	+	NA	NA	NA	[298]

+++: Strong expression; ++: Moderate expression; +: Low expression; -: No expression; NA: Not available; LPAR: Lysophosphatidic acid receptor; NHBEs: Normal human bronchial epithelial; HBE: Human bronchial epithelial; HBEpCs: Human bronchial epithelial cells; NHLFs: Normal human lung fibroblasts; ECs: Endothelial cells; HPAECs: Human pulmonary arterial ECs; HMVECs: Human pulmonary microvascular ECs; HMVECs: Human pulmonary microvascular ECs; HEVs: High endothelial venules; DCs: Dendritic cells.