Copyright
©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Hypocretin (orexin) pathology in Alzheimer’s disease
Thomas C Thannickal, Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA 90025, United States
Thomas C Thannickal, Veterans Administration Greater Los Angeles Healthcare System, Neurobiology Research (151A3), North Hills, CA 91343, United States
Author contributions: Thannickal TC solely contributed to this work.
Conflict-of-interest statement: None.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Thomas C Thannickal, PhD, Associate Researcher, Veterans Administration Greater Los Angeles Healthcare System, Neurobiology Research (151A3), North Hills, 16111 Plummer St., CA 91343, United States. thomastc@ucla.edu
Telephone: +1-818-8917711 Fax: +1-818-8959575
Received: January 29, 2015
Peer-review started: January 30, 2015
First decision: April 27, 2015
Revised: June 4, 2015
Accepted: July 16, 2015
Article in press: July 17, 2015
Published online: September 28, 2015
Peer-review started: January 30, 2015
First decision: April 27, 2015
Revised: June 4, 2015
Accepted: July 16, 2015
Article in press: July 17, 2015
Published online: September 28, 2015
Core Tip
Core tip: Hypocretin plays an important role in the control of sleep-wake cycle. Increased hypocretin levels in Alzheimer’s disease patients suggest hypocretin system is involved during development of the disease symptoms.