Ex vivo expansion of hematopoietic stem and progenitor cells: Recent advances

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May 6, 2014 (publication date) through May 9, 2024

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World Journal of Hematology

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2218-6204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Hematol. May 6, 2014; 3(2): 18-28
Published online May 6, 2014. doi: 10.5315/wjh.v3.i2.18

Table 1 Comparison of the sources for hematopoietic stem cells

	Advantages	Disadvantages
Bone marrow	1 The longest history as a source of HSC	1 High stringency for HLA matching
	2 Well established procedure	2 Some complications associated with harvesting
		3 Risk of GVHD
Umbilical cord blood	1 Off-the-shelf availability	1 Delayed engraftment
	2 Reduced stringency for HLA matching	2 Lower yield
	3 Low risk of infection/transmission	3 Lack of additional immune cells
	4 Absence of donor risk
Peripheral blood	Compared to BM,	1 Extremely low level of HSC (1/100000) without “mobilization”
	1 More comfortable for donors	2 Risk of GVHD
	2 Better yield with mobilization

HSC: Hematopoietic stem cell; HLA: Human leukocyte antigen; BM: Bone marrow; GVHD: Graft-versus-host disease.

Table 2 Cell-surface makers of undifferentiated hematopoietic stem cells

Mouse	Human
CD34^low/-	CD34^low/-
Sca-1⁺	Sca-1⁺
CD90/Thy-1^+/low	CD90/Thy-1^+/low
c-Kit⁺	c-Kit⁺
CD38⁺	CD38^-
CD150⁺	CD7^-
Side population (high hoechst-efflux activity)	CD49f⁺
CD48^-	Rhodamine 123^low
CD244^-	CD133/AC133^-
Lin^-	CD45RA^-
	Lin^-

Citation: Kita K, Xiu F, Jeschke MG. Ex vivo expansion of hematopoietic stem and progenitor cells: Recent advances. World J Hematol 2014; 3(2): 18-28
URL: https://www.wjgnet.com/2218-6204/full/v3/i2/18.htm
DOI: https://dx.doi.org/10.5315/wjh.v3.i2.18