Changing insights in the diagnosis and classification of autosomal recessive and dominant von Willebrand diseases 1980-2015

Figure 5 The 1986 Zimmerman Classification of Von Willebrand disease type IIA, IIB, IIC, IID and IIE[9] and Dr. Ted Zimmerman (1937-1988). SDS-agarose multimeric analysis of plasma VWF in normal plasma (N) and in VWD type IIA, IIB, IIC, IIE and IID. Left lower part: Immunoblots of VWF proteolytic degradation products show increased proteolysis in VWD type IIA and IIB, but not or even absent in VWD type IIC, IIE and IID (N = normal plasma). VWD: Von Willebrand disease; VWF: Von Willebrand factor.