Insights into myelodysplastic syndromes from current preclinical models

Table 1 Bethesda diagnostic criteria for myeloid dysplasia in mice

(1) At least one of the following

A: Neutropenia

B: Thrombocytopenia (without leucocytosis or erythrocytosis)

C: Anemia (without leucocytosis or thrombocytosis)

(2) Maturation defect in myeloid cells manifest as at least one of

A: Dysgranulopoiesis, dyserythropoiesis, or dysplastic megakaryocytes with or without increased myeloid immature forms or blasts

B: At least 20% myeloid immature forms or blasts

(3) Disorder is not AML

Subclassification

Myelodysplastic syndrome if meeting criteria (2)A

Cytopenia with increased blasts if meeting (2)B

Summarised from Kogan et al[60]. AML: Acute myeloid leukemia.