Role of novel oral anticoagulants in the management and prevention of venous thromboembolism

Table 3 Efficacy and safety

	Incidence of recurrent VTE			Incidence of major bleeding
	NOAC	Warfarin	HR (95%CI)	NOAC	Warfarin	HR (95%CI)
RE-COVER	2.4%	2.1%	1.10 (0.65-1.84)	1.6%	1.9%	0.82 (0.45-1.48)
RE-COVER II	2.3%	2.2%	1.08 (0.45-1.48)	1.2%	1.9%	0.69 (0.36-1.32)
RE-MEDY1	1.8%	1.3%	1.44 (0.78-2.64)	0.9%	1.8%	0.52 (0.27-1.02)
EINSTEIN DVT	2.1%	3.0%	0.68 (0.45-1.48)	0.8%	1.2%	0.65 (0.33-1.30)
EINSTEIN PE	2.1%	1.8%	1.12 (0.75-1.68)	1.1%	2.2%	0.49 (0.31-0.79)
AMPLIFY	2.3%	2.7%	0.84 (0.60-1.18)	0.6%	1.8%	0.31 (0.17-0.55)
HOKUSAI-VTE	3.2%	3.5%	0.89 (0.70-1.13)	1.4%	1.6%	0.84 (0.59-1.21)

¹Extended treatment study. NOAC: Novel oral anticoagulant; DVT: Deep vein thrombosis; PE: Pulmonary embolism; VTE: Venous thromboembolism.