Follicular helper T lymphocytes in health and disease

doi:10.5315/wjh.v3.i4.118

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 3, Issue 4

This Article

Academic Content and Language Evaluation of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (14407)

All Articles published online

The chart showing PDF series, WORD series, HTML series, Figures (1-3) series, Tables (1-3) series.

Item

Count

PDF

667

WORD

478

HTML

8315

Figures (1-3)

722

Tables (1-3)

170

Sum=10352

Featured Article

The chart showing Browse series, Download series.

Item

Count

Browse

586

Download

1192

Sum=1778

Publishing Process of This Article

Item

Count

Browse

1103

Download

1174

Sum=2277

Nov 6, 2014 (publication date) through Apr 24, 2024

Times Cited of This Article

Times Cited (5)

Journal Information of This Article

Publication Name

World Journal of Hematology

ISSN

2218-6204

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Review

World J Hematol. Nov 6, 2014; 3(4): 118-127
Published online Nov 6, 2014. doi: 10.5315/wjh.v3.i4.118

Table 1 Follicular helper T lymphocytes markers

Marker	Human T_FH		NaïveCD4⁺ T cell	ActivatedNon-T_FH CD4⁺
Marker	T_FH	GC T_FH		ActivatedNon-T_FH CD4⁺
CXCR5	+	++	NaïveCD4⁺ T cell	-	-
Ascl2	?	++	?	?
Bcl-6	+	++	-	-
Blimp-1	-	-	+/-	++/variable
PD-1	+	++	-	Variable
ICOS	+	++	-	Variable
SAP	+	++	+	+
IL-21	+	++	-	Variable
IL-4	-/+	++	-	Th2+
CCR7	-/+	-	++	Variable

T_FH: Follicular helper T lymphocytes; GC: Germinal center; CXCR5: Chemokine (C-X-C motif) receptor 5; Ascl2: Achaete-scute homologue 2; Bcl-6: B cell lymphoma 6; Blimp-1: B lymphocyte-induced maturation protein 1; PD-1: Programmed cell death-1; ICOS: Inducible costimulator; SAP: Signaling adaptor SLAM-associated protein; IL: Interleukin; CCR7: Chemokine (C-C motif) receptor 7; Th: T helper.

Citation: Parodi C, Badano MN, Galassi N, Coraglia A, Baré P, Malbrán A, Bracco MME. Follicular helper T lymphocytes in health and disease. World J Hematol 2014; 3(4): 118-127
URL: https://www.wjgnet.com/2218-6204/full/v3/i4/118.htm
DOI: https://dx.doi.org/10.5315/wjh.v3.i4.118