Review
Copyright ©2014 Baishideng Publishing Group Inc.
World J Hematol. Aug 6, 2014; 3(3): 49-70
Published online Aug 6, 2014. doi: 10.5315/wjh.v3.i3.49
Table 1 Features at primary diagnosis of acute lymphoblastic leukaemia associated with an increased risk of relapse[3]
Clinical featuresHigh-risk group stratification1
AgeInfants < 1 yr oldYes
≥ 10 yrYes2
WBC≥ 50 × 109/LYes2
SexMaleNo
EthnicityBlacksNo
Native AmericanNo
Alaskan NativeNo
HispanicNo
CNS statusCNS3No
Response to therapy
Morphological responsePPRYes
Induction failure3Yes
MRD ≥ 0.01%After induction (day 33)Yes
After consolidation (day 78)
Biology
ImmunophenotypeT-cellNo
Early T-cell precursorAccepted by some study groups
Genetic alterationsBCR-ABL1Yes
MLL translocationYes if age < 1 yr
Hypodiploidy (< 44 chromosomes)Yes
TCF3-PBX1 (E2A-PBX1)No
TCF3-HLFAccepted by some study groups
iAMP21Accepted by some study groups
BCR-ABL1-like ALL4No
IKZF1 mutation or deletionNo