Anti-CD20 monoclonal antibodies and associated viral hepatitis in hematological diseases

Table 1 Anti-CD20 monoclonal antibodies and associated hepatitis

Antibody	Structure	Clinical applications	Associated hepatitis	Ref.
Rituximab	IgG1, chimeric murine/human mAb	B-cell NHL, RA, SLE, MS, AIHA, TTP, ITP, acquired hemophilia, cryoglobulinemia	HBV, HCV, parvovirus B19, VZV, adenovirus, HEV, drug-related?	[14,18-35,60-65,71, 73,74,78,85,89-93,102-111, 140-147,172,174-179]
Y-90 ibritumomab tiuxetan	IgG1, mouse mAb, conjugated with tiuxetan to yttrium-90	B-cell NHL	HBV	[36-38,112]
I-131 tositumomab	IgG2, mouse mAb, covalently bound to iodine-131	B-cell NHL	None	[39-44]
Ofatumumab	IgG1, human mAb	CLL, B-cell NHL, RA, MS, AIHA	HBV or drug-related?	[45-50,68,114-116]
Veltuzumab	IgG1, humanized mAb	B-cell NHL, ITP	Drug-related?	[51,69]
Ocrelizumab	IgG1, humanized mAb	B-cell NHL, RA, SLE, MS	None	[52]
Obinutuzumab	IgG1, humanized mAb, modified Fc	CLL, B-cell NHL	Drug-related?	[53-57]
PRO131921	IgG1, humanized mAb, modified Fc	CLL, B-cell NHL	None	[58]
Ocaratuzumab	IgG1, humanized mAb, modified Fc	B-cell NHL	None	[59]

mAb: Monoclonal antibody; NHL: Non-Hodgkin lymphoma; RA: Rheumatoid arthritis; SLE: Systemic lupus erythematosus; MS: Multiple sclerosis; AIHA: Autoimmune hemolytic anemia; TTP: Thrombotic thrombocytopenic purpura; ITP: Immune thrombocytopenic purpura; DM: Diabetes mellitus; HBV: Hepatitis B virus; HCV: Hepatitis C virus; VZV: Varicella-zoster virus; HEV: Hepatitis E virus; CLL: Chronic lymphocytic leukemia; None: No associated hepatitis reported in hematological autoimmune disorders or malignancies at the time of review (excluding non-hematological diseases).