PVSG and WHO vs European Clinical, Molecular and Pathological Criteria for prefibrotic myeloproliferative neoplasms

Figure 2 Bone Marrow diagnosis alone: chronic megakaryocytic granulocytic myeloproliferation by Georgii et al[24] vs chronic idiopathic myelofibrosis by Thiele et al[29,75], and comparative World Health Organization and European Clinical, Molecular and Pathological criteria for prefibrotic essential thrombocythemia, polycythemia vera and primary megakaryocytic and granulocytic myeloproliferation or chronic idiopathic myelofibrosis/primary myelofibrosis or agnogenic myeloid metaplasia. Translation of Polycythemia Vera Study Group (PVSG) and 2008 World Health Organization (WHO) defined essential thrombocythemia (ET), polycythemia vera (PV) and chronic idiopathic myelofibrosis (CIMF), chronic megakaryocytic granulocytic myeloproliferation (CMGM) or primary megakaryocytic and granulocytic myeloproliferation (PMGM) according to European Clinical, Molecular and Pathological (ECMP) criteria subdivided in JAK2^V617F mutated ET, prodromal PV, overt PV and ET.MGM (red) vs prefibrotic PMGM (blue) and 2 types of normocellular ET (JAK2^V617F + left red, MPL⁵¹⁵ + black). PMF: Primary myelofibrosis; AMM: Agnogenic myeloid metaplasia; ET.MGM: ET due to megakaryocytic, granulocytic myeloproliferation; MF: Myelofibrosis.