Aspirin responsive platelet thrombophilia in essential thrombocythemia and polycythemia vera

Table 2 Clinical manifestations and sequence of aspirin-responsive microvascular cerebral ischemic attacks in each of 17 patients with essential thrombocythemia

	Patient nubmer
	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17
Thrombotic events sequence	MI	VS	CS	VS	MI	VS	CS	CS	CS	E	CS	CS	E	CS	CS	VS	CS
	CS	E	VS	CS	VS	E	AP	VS	VS	VS	AP	E	CS	E	E	CS	E
			E		CS					CS
					AP					E
										MI
Time lapse of sequential thrombotic events (yr)	2	5	2	3	5	4	1	3	1	7	4	3	2	1	3	1	4
Cerebral and visual symptoms
Transient hemiparesis	+				+						+	+		+	+	+
Unstable gait	+		+	+	+		+	+	+	+	+	+		+		+	+
Dysarthria			+		+		+		+			+	+	+			+
Transient monocular blindness		+							+							+
Scintillating scotomata		+		+	+	+
Blurred vision		+	+	+	+	+		+	+	+						+	+
Headache	+	+		+	+	+		+	+					+	+	+
Number of attacks	S	M	S	S	M	S	S	F	S	F	S	S	F	S	F	M	S

Because of ignorance of a causal relationship between microvascular cerebral ischemic attacks and essential thrombocythemia by the referring doctors, the time lapses between sequential microthrombotic events were prolonged ranging from 1 to 7 years. MI: Myocardial infarction; CS: Cerebral symptoms; VS: Visual symptoms; AP: Angina pectoris; E: Erythromelalgia. Number of attacks: F: Few; S: Several 4-10; M: More than 10. Source Michiels et al[31].