Establishing minimum clinically important difference values for the Patient-Reported Outcomes Measurement Information System Physical Function, hip disability and osteoarthritis outcome score for joint reconstruction, and knee injury and osteoarthritis outcome score for joint reconstruction in orthopaedics

Table 1 Demographics of patients (n = 2226)

Patient characteristics	n	Percent	Mean (SD)	Range
Age (yr)			61.16 (12.84)	18-93
Gender
Male	927	41.6
Female	1299	58.4
Race
White or Caucasian	1997	89.7
Black or African
American 27	1.2
Asian	20	0.9
American Indian and Alaska Native	32	1.4
Native Hawaiian or Pacific Islander	11	0.5
Other	113	5.1
Unknown/missing	26	1.2
Ethnicity
Hispanic	114	5.1
Non-Hispanic	2075	93.2
Missing	37	1.7

Table 2 Anchor-based methods for minimum clinically important difference determination of the PROMIS PF CAT, HOOS JR and KOOS JR

Instrument	n	No change (SD)	n	Mean change (SD)	ROC cut-off
3-mo from baseline follow-up
PF CAT	54	6.95 (6.70)	88	7.60 (4.98)	1.97
HOOS JR	6	22.81 (10.10)	24	14.81 (12.45)	43.36
KOOS JR	14	10.49 (10.00)	37	14.51 (9.76)	7.24
> 3-mo from baseline follow-up
PF CAT	366	6.02 (5.40)	577	7.29 (7.31)	3.44
HOOS JR	48	14.34 (15.23)	110	18.49 (12.53)	8.07
KOOS JR	96	12.71 (12.62)	151	14.82 (12.56)	8.16
6-mo from baseline follow-up
PF CAT	21	4.36 (4.32)	34	8.41 (6.12)	3.52
HOOS JR	6	6.62 (5.87)	5	19.68 (18.65)	7.45
KOOS JR	12	13.49 (11.07)	14	18.85 (12.82)	6.12
> 6-mo from baseline follow-up
PF CAT	192	6.44 (5.83)	421	7.69 (6.75)	8.18
HOOS JR	76	12.58 (11.61)	57	17.57 (13.92)	6.33
KOOS JR	81	12.45 (10.77)	64	15.47 (13.38)	2.21

Table 3 Distribution-based methods for minimum clinically important difference determination of the PROMIS PF CAT, HOOS JR and KOOS JRKOOS JR

Instrument	n	SD		MDC
		1/2	1/3	90%	95%	99%
3-mo from baseline follow-up
PF CAT	663	3.68	2.45	11.64	14.14	18.47
HOOS JR	99	5.86	3.9	17.54	20.84	27.22
KOOS JR	129	6.52	4.35	24.49	29.09	37.99
> 3-mo from baseline follow-up
PF CAT	2133	4.02	2.68	12.47	14.82	19.35
HOOS JR	245	9.33	6.22	28.11	33.39	43.61
KOOS JR	365	8.02	5.34	26.21	31.14	40.67
6-mo from baseline follow-up
PF CAT	264	3.93	2.62	13.89	16.5	21.55
HOOS JR	31	10.96	7.3	26.36	31.31	40.89
KOOS JR	55	5.96	3.98	20.84	24.75	32.33
> 6-mo from baseline follow-up
PF CAT	1520	4.35	2.9	13.46	15.98	20.88
HOOS JR	112	10.73	7.15	28.86	31.9	41.67
KOOS JR	154	7.12	4.75	22.91	27.22	35.55

MDC: Minimum detectable change.