Vascular endothelial growth factor for the treatment of femoral head osteonecrosis: An experimental study in canines

Figure 1 Cryosurgically-induced osteonecrosis of the femoral head (No-t group). The specimen was retrieved 12 wk postoperatively. A: Cancellous lamellar bone (T) with empty bone lacunae (L) marked with arrows, and fibrotic/loose connective tissue marrow space (F), indicating osteonecrosis (Obj. × 10, H and E); B: Lamellar compact bone (Lm) of cortical type, in between spaces filled with adipose tissue (A). The absence of nuclei in osteocyte’s lacunae (L) (marked with arrows) indicates that the bone is necrotic (Obj. × 10, TB).