Copyright
©The Author(s) 2017.
World J Orthop. Oct 18, 2017; 8(10): 798-808
Published online Oct 18, 2017. doi: 10.5312/wjo.v8.i10.798
Published online Oct 18, 2017. doi: 10.5312/wjo.v8.i10.798
Procedure | Product | Scientific publication | Type of study | LOE | No. of patients | Lesion size (cm2) | Follow-up (mo) | Results |
Two-step | ||||||||
MACT | MACI | Schneider et al[6], 2009 | Case series | IV | 20 | 2.3 | 21 | Significant improvement in functional score |
Pain improved in 70% of patients | ||||||||
Giza et al[5], 2010 | Case series | IV | 10 | 1.3 | 24 | Significant clinical improvement at 1 yr and maintained at 2 yr | ||
Aurich et al[16], 2011 | Case series | IV | 18 | - | 25 | Significant improvement in all clinical scores 64% were excellent or good Age and symptoms duration were correlated with results | ||
Dixon et al[17], 2011 | Case series | IV | 25 | 1.3 | 44 | 72% improved symptoms 78% patients over 40 yr reported restricted recreational activity | ||
Lee et al[18], 2013 | Case series | IV | 38 | 1.9 | 24 | Functional outcomes improved significantly at 2 yr 68% were excellent or good outcome 75% ICRS grade I or II in 2nd look arthroscopy at 1 yr | ||
Johnson et al[19], 2013 | Case series | IV | 18 | 1.9 | 82 | Functional outcomes improved at final follow-up | ||
Giannini et al[20], 2014 | Case series | IV | 46 | 1.6 | 87 | Significant clinical improvement at 1 yr and maintained at 3 yr; 3 failures | ||
Hyalograft C | Giannini et al[21], 2008 | Case series | IV | 46 | 1.6 | 36 | Significant clinical improvement at 1 yr and 3 yr Results correlated with age and previous surgery Hyaline-like cartilage regeneration in histological evaluation | |
Battaglia et al[22], 2011 | Case series | IV | 20 | 2.7 | 60 | Significant clinical improvement T2 mapping MRI showed 69% of lesion are covered with repair tissue | ||
Nehrer et al[23], 2011 | Case series | IV | 13 | - | 47 | Significant clinical improvement in all cases | ||
Domayer et al[24], 2012 | Comparative study | III | 18 | 1.2 | 65 | Significant clinical improvement but no significant difference compared to MFX group No difference between MFX and MACT on T2 maps | ||
Apprich et al[25], 2012 | Case series | IV | 10 | 1.2 | 48 | Significant clinical improvement No differences in functional outcome and MOCART score between MFX and MACT | ||
Two-step | ||||||||
BMDCT | Spontostan Powder HYAFF-11 | Giannini et al[8], 2009 | Case series | IV | 48 (25 HA membrane, 23 collagen powder) | 2.1 | 29 | Significant clinical improvement at 1 yr maintained at 2 yr Similar results with two scaffolds Correlation between clinical outcome and lesion size |
Spontostan Powder HYAFF-11 | Giannini et al[26], 2010 | Comparative study | III | 25 BMDCT 46 two-step MACI | 2.2 1.6 | 39 57 | Significant clinical improvement at 1 yr and further improvement at 3 yr 76% complete intergration with surrounding cartilage on MRI Hyaline-like cartilage tissue on histological evaluation | |
HYAFF-11 | Battaglia et al[27], 2011 | Case series | IV | 20 | 1.5 | 24 | 85% excellent or good clinical results at 2 yr 78% of lesion are covered with repair tissue comparable to hyaline cartilage | |
Spontostan Powder HYAFF-11 | Giannini et al[28], 2013 | Case series | IV | 49 | 2.1 | 29 | Significant clinical improvement at 1 yr with subsequent significant decrease at 2 and 3 yr 78% of repaired tissue similar to hyaline cartilage on T2 maps | |
Spongostan Powder | Buda et al[29], 2014 | Case series | IV | 64 | 5.3 | 53 | Clinical results peaked at 2 yr, declining gradually at follow-up of 6 yr | |
Biopad | Cadossi et al[30], 2014 | Comparative study | III | 15 BMDCT 15 BMDCT with PEMF | 2 1.9 | 12 12 | Significant clinical improvement in both groups | |
HYAFF-11 | Buda et al[4], 2015 | Case series | IV | 40 | 1.8 | 48 | Significant clinical improvement Higher presence of hyaline-like cartilage in BMDCT than ACI on MRI T2 mapping | |
HYAFF-11 Spongostan Powder Biopad | Vannini et al[31], 2017 | Case series | IV | 140 | 2 | 26 | Significant clinical improvement at 2 yr maintained at 4 yr Return to sports at preinjury level; 32.1% at 12 mo, 72.8% at 48 mo | |
AMIC | Unclear | Wiewiorski et al[7], 2013 | Case series | IV | 23 | - | 23 | Significant clinical improvement |
Chondro-Gide | Valderrabano et al[32], 2013 | Case series | IV | 26 | - | 31 | Significant clinical improvement Normal signal intensity of repair tissue was seen in 15% on MRI | |
Chondro-Gide | Kubosch et al[33], 2016 | Case series | IV | 17 | 2.4 | 39 | Significant clinical improvement MOCART score correlated with AOFAS score | |
Chondro-Gide | Wiewiorski et al[34], 2016 | Case series | IV | 60 | - | 47 | Calcaneal osteotomy was performed in 63% of patients Low rate for return to sports; postoperative sports activity levels remain stable when compared with preoperative levels | |
Cartilage ECM | BioCartilage | Desai S[35], 2016 | Case series | IV | 9 | 1.3 | 12 | 78% excellent, 22% good clinical outcomes |
Clanton et al[36], 2014 | Case series | IV | 7 | - | 8 | Significant clinical improvement | ||
ACIC | Cartifill | Volpi P et al[37], 2014 | Case series | IV | 5 | 3.1 | 6 | Significant clinical improvement at 6 mo |
Cell-free scaffold | MaioRegen® | Christensen et al[38], 2015 | Case series | IV | 4 | - | 30 | No clinical scores improvement No improvement in MOCART score and 3 patients had 0%-10% bone formation in defect at 1 yr on CT |
- Citation: Shimozono Y, Yasui Y, Ross AW, Miyamoto W, Kennedy JG. Scaffolds based therapy for osteochondral lesions of the talus: A systematic review. World J Orthop 2017; 8(10): 798-808
- URL: https://www.wjgnet.com/2218-5836/full/v8/i10/798.htm
- DOI: https://dx.doi.org/10.5312/wjo.v8.i10.798