Meta-Analysis
Copyright ©The Author(s) 2015.
World J Orthop. Nov 18, 2015; 6(10): 838-846
Published online Nov 18, 2015. doi: 10.5312/wjo.v6.i10.838
Table 3 Grading of Recommendations Assessment, Development, and Evaluation summary findings: Operative vs non-operative treatment in proximal humeral fractures
OutcomesNo. of Participants(studies)Quality of the evidence (GRADE)Relative effect(95%CI)Anticipated absolute effects
Follow upRisk difference between non-operative and operative1 (95%CI)
Physical Function by Constant score - long term229 (5 studies)Moderate due to risk of biasThe mean physical function by constant score-long term in the intervention group was 1.63 higher (2.84 lower to 6.11 higher)
Health Related Quality of Life - long term154 (3 studies)Moderate due to risk of biasThe mean health related quality of life - long term in the intervention group was 0.23 standard deviations higher (0.09 lower to 0.54 higher)
Constant pain - long term229 (5 studies)Low due to risk of bias, inconsistencyThe mean Constant pain - long term in the intervention group was 0.28 higher (1.01 lower to 1.57 higher)
Mortality rate247 (5 studies)Moderate due to risk of biasRR 1.14 (0.45 to 2.86)Study population
56 per 10008 more per 1000 (from 31 fewer to 105 more)
Moderate
63 per 10009 more per 1000 (from 35 fewer to 117 more)
Re-operation Rate247 (5 studies)Low due to risk of bias, imprecisionRR 3.62 (1.38 to 9.49)Study population
32 per 100085 more per 1000 (from 12 more to 274 more)
Moderate
36 per 100094 more per 1000 (from 14 more to 306 more)