Diabetic foot syndrome: Immune-inflammatory features as possible cardiovascular markers in diabetes

Table 8 Diabetic foot infection classification schemes: Infectious Diseases Society of America Infectious Diseases

Clinical description	Infectious Diseases Society of America
Wound without purulence or any manifestations of inflammation	Uninfected
≥ 2 Manifestations of inflammation (purulence or erythema, pain, tenderness, warmth, or induration); anyc ellulitis or erythemaextends 52 cm around ulcer, and infection is limited to skin or superficial subcutaneous stissues; no localcomplications or systemic illness	Mild
Infection in a patientwho is systemicallywell and metabolicall ystable buthas 2 cm; lymphangitis; spread beneath fascia; deeptissue abscess; gangrene; muscle, tendon, joint, or bone involvement	Moderate
Infection in a patient with systemic toxicity or metabolic instability (e.g., fever, chills, tachycardia, hypotension, confusion, vomiting, leukocytosis, acidosis, hyperglycemia, or azotemia)	Severe

Adapted from Lavery et al[67].