New perspectives for articular cartilage repair treatment through tissue engineering: A contemporary review

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World Journal of Orthopedics

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2218-5836

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Orthop. Apr 18, 2014; 5(2): 80-88
Published online Apr 18, 2014. doi: 10.5312/wjo.v5.i2.80

Table 3 Overview of advantages and disadvantages of various scaffolds

Cells	Material	Results
Chondrocyctes	Poly(epsilon-caprolactone)-block-poly(L-lactide)	Applicable for cartilage tissue engineering
Rabbit marrow mesenchymal stem cells	Oligo(poly(ethylene glycol) fumarate) with encapsulated cells and gelatin microparticles loaded with TGF-β1	Maintained viability of cells for 14 d
Rabbit marrow mesenchymal stem cells		Differentiation of cells into chondrocyte-like cells
Chondrocytes	Gelatin microparticle aggregates, +/- TGF-β1	Supported viability and function of chondrocytes
Chondrocytes	Gelatin microparticle aggregates, +/- TGF-β1	Applications in cartilage-engineering
Human adipose derived stem cells	Genipin-crosslinked cartilage derived matrix	Using genipin resulted in contraction free biomaterial.
Human adipose derived stem cells	Genipin-crosslinked cartilage derived matrix	Chondrogenesis
Human mesenchmal stem cells	Poly(epsilon-caprolactone)	Cell colonization, proliferation and osteogenic differentiation were related to the micro-architecture of the pore structure
Human chondrocytes	Blend of poly (lactic-co-glycolic acid) and polyvinyl alcohol	Supported cell adhesion and growth
Human chondrocytes		After implantation, there was better bone in-growth and bone formation inside the scaffold.
Bone marrow stem cells	Polyglycolic acid, poly (lactic acid)	Cell infiltrated the scaffold
		Good cellular compatibility
		Applicable to repair craniomaxillofacial bone defects

TGF: Transforming growth factor.

Citation: Musumeci G, Castrogiovanni P, Leonardi R, Trovato FM, Szychlinska MA, Di Giunta A, Loreto C, Castorina S. New perspectives for articular cartilage repair treatment through tissue engineering: A contemporary review. World J Orthop 2014; 5(2): 80-88
URL: https://www.wjgnet.com/2218-5836/full/v5/i2/80.htm
DOI: https://dx.doi.org/10.5312/wjo.v5.i2.80

Musumeci G, Castrogiovanni P, Leonardi R, Trovato FM, Szychlinska MA, Di Giunta A, Loreto C, Castorina S. New perspectives for articular cartilage repair treatment through tissue engineering: A contemporary review. World J Orthop 2014; 5(2): 80-88 [PMID: 24829869 DOI: 10.5312/wjo.v5.i2.80]

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