RANKL, a necessary chance for clinical application to osteoporosis and cancer-related bone diseases

doi:10.5312/wjo.v4.i4.207

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Oct 18, 2013 (publication date) through Apr 24, 2024

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World Journal of Orthopedics

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2218-5836

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Orthop. Oct 18, 2013; 4(4): 207-217
Published online Oct 18, 2013. doi: 10.5312/wjo.v4.i4.207

Table 2 Comparison of serum soluble RANKL concentrations among various mouse models

Mouse model	sRANKL (ng/mL)	Phenotype
Ad-sRANKL injection (High)	1500	Severe osteoporosis/hypercalcemia
Ad-sRANKL injection (Low)	233	Severe osteoporosis/hypercalcemia
sRANKL-Tg mice	30	Severe osteoporosis
GST-RANKL injection	3.5¹	Osteoporosis
Wild mice	0.1	Normal

¹Serum glutathione-S transferase-receptor activator of nuclear factor-κB ligand (GST-RANKL) concentration 4 h after injection of 1 mg/kg GST-RANKL. sRANKL: Soluble RANKL; Ad-sRANKL: Harboring mouse sRANKL cDNA.

Citation: Yasuda H. RANKL, a necessary chance for clinical application to osteoporosis and cancer-related bone diseases. World J Orthop 2013; 4(4): 207-217
URL: https://www.wjgnet.com/2218-5836/full/v4/i4/207.htm
DOI: https://dx.doi.org/10.5312/wjo.v4.i4.207