Effect of liposomal bupivacaine for iliac fascia block on postoperative cognitive dysfunction in patients with femoral neck fractures

doi:10.5312/wjo.v17.i5.116844

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World Journal of Orthopedics

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2218-5836

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Randomized Controlled Trial

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Orthop. May 18, 2026; 17(5): 116844
Published online May 18, 2026. doi: 10.5312/wjo.v17.i5.116844

Table 4 Comparison of visual analog scale scores for resting pain and exercise pain at each time point between the two patient groups, median (25^th-75^th percentiles)

Indicator	Group	T0	T1	T3	T4	T5
Rest VAS score	Control (n = 40)	6.0 (5.0-6.0)	6.0 (5.0-6.0)	2.0 (2.0-3.0)	4.0 (3.0-4.0)	4.0 (4.0-5.0)
Rest VAS score	LB (n = 40)	6.0 (5.0-6.0)	3.0 (2.0-4.0)^a	2.0 (1.0-2.0)^a	2.0 (2.0-3.0)^a	3.0 (3.0-4.0)^a
z value		-0.045	-3.771	-3.053	-4.340	-3.748
P value		0.964	0.000	0.002	0.000	0.000
Exercise VAS score	Control (n = 40)	8.0 (8.0-9.0)	8.0 (6.00-8.00)	3.0 (3.00-4.00)	4.0 (4.00-5.00)	4.0 (4.0-5.0)
Exercise VAS score	LB (n = 40)	9.0 (8.0-9.0)	4.0 (3.00-4.00)^a	2.00 (2.00-3.00)^a	3.0 (2.00-4.00)^a	4.0 (3.0-4.0)^a
z value		-0.783	-2.962	-3.968	-4.547	-3.092
P value		0.433	0.003	0.000	0.000	0.002

^aP < 0.05.

Visual analogue scale score ranges from 0 to 10, 0 = no pain, 10 = worst pain. LB: Liposomal bupivacaine; VAS: Visual analogue scale; T0: One day before surgery; T1: Upon entering the operating room; T2: 6 hours after surgery; T3: 12 hours after surgery; T4: 24 hours after surgery; T5: 48 hours after surgery.

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Citation: Liu H, Jia T, Shuai SC, Zhao JB. Effect of liposomal bupivacaine for iliac fascia block on postoperative cognitive dysfunction in patients with femoral neck fractures. World J Orthop 2026; 17(5): 116844
URL: https://www.wjgnet.com/2218-5836/full/v17/i5/116844.htm
DOI: https://dx.doi.org/10.5312/wjo.v17.i5.116844

Liu H, Jia T, Shuai SC, Zhao JB. Effect of liposomal bupivacaine for iliac fascia block on postoperative cognitive dysfunction in patients with femoral neck fractures. World J Orthop 2026; 17(5): 116844 [DOI: 10.5312/wjo.v17.i5.116844]

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