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Systematic Reviews
Copyright: ©Author(s) 2026.
World J Orthop. Apr 18, 2026; 17(4): 116521
Published online Apr 18, 2026. doi: 10.5312/wjo.v17.i4.116521
Table 3 Outcome evaluations between intervention and placebo groups
Ref.
Measured outcomes
Results
Brewer et al[6], 2022Pain (NRS)Lower postoperative pain (P = 0.02), lower kinesiophobia (P = 0.77), improved postoperative symptoms (P = 0.002) in cases than controls
Kinesiophobia (TSK)No significant difference in flexion ROM (P = 0.99), extension ROM (P = 0.18), and knee laxity (P = 0.09) between groups
Subjective symptoms (KOS-SAS)
Knee laxity (KT1000)
ROM (flex and ext)
Rhim et al[8], 2020Kinesiophobia (TSK)No significant difference in self-efficacy (P = 0.808), return to sport (P = 0.574), kinesiophobia (P = 0.888), and KOOS subscales (P = 0.236 to 0.916) between groups
Return to sport (ACL-RSI)
Self-efficacy (K-SES)
Functional status (KOOS)
Levinger et al[7], 2017Self-efficacy (K-SES)No significant difference in KOOS subscales (P = 0.07-0.76), self-efficacy subscales (P = 0.42 and 0.71), kinesiophobia (P = 0.46), fear of activity (P = 0.96) between groups
Functional status (KOOS)
Kinesiophobia (TSK)
FABQ
Zaffagnini et al[9], 2013QOL (mental and physical SF-36)Improved subjective IKDC (P = 0.047), TKS (P = 0.0141) and time to crutches discharge (P = 0.0012). No significant difference in Tegner score, and SF-36 mental and physical status between groups
Kinesiophobia (TSK)
Functional (subjective and objective IKDC, Tegner)
Crutches use time
Lebon et al[4], 2012Isometric activation of the medial musculature (EMG during maximum knee extension)Greater postoperative musculature activity in cases than controls (P = 0.02). No significant difference in postoperative pain, ROM, effusion reduction, thigh circumference, LEFS score (P > 0.05) between groups
Pain (VAS score)
Ability to perform daily activities with lower extremity injury using the LEFS
Magnitude of surgical effusion and atrophy by the circumference of the knee above the kneecap and circumference of the thigh 15 cm above the kneecap
Knee ROM (goniometry)
Cupal and Brewer[3], 2001Pain (0-10 scale)Improved pain in cases than placebos (P < 0.05). Reduced re-injury anxiety in cases than placebos (P < 0.05). Greater post-op knee strength in cases than placebos (P < 0.003)
Reinjury anxiety (0-10 scale)
Knee strength (cybex 6000)
Isokinetic dynamometer


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