Xianling Gubao capsule alleviates osteoporosis: Modulation of gut-bone axis and Wnt signaling

doi:10.5312/wjo.v17.i4.116046

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World Journal of Orthopedics

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2218-5836

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Orthop. Apr 18, 2026; 17(4): 116046
Published online Apr 18, 2026. doi: 10.5312/wjo.v17.i4.116046

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Figure 8 Multivariate statistical analysis and model validation of fecal metabolomics in ovariectomy rats treated with Xianling Gubao capsule. A: Orthogonal projections to latent structures discriminant analysis (OPLS-DA) score plot in negative ion mode; B: OPLS-DA score plot in positive ion mode; C: Permutation test validating the stability and predictive ability of the OPLS-DA model in positive ion mode; D: Permutation test validating the stability and predictive ability of the OPLS-DA model in negative ion mode. The data are expressed as means ± SD (n = 5). XLGB: Xianling Gubao capsule; OVX: Ovariectomy; Sham: Sham-operated.

Citation: Yu AX, Liang WH, Zhou YS, Li P, Ji JM, Zhang FW, Yu P, Liu J. Xianling Gubao capsule alleviates osteoporosis: Modulation of gut-bone axis and Wnt signaling. World J Orthop 2026; 17(4): 116046
URL: https://www.wjgnet.com/2218-5836/full/v17/i4/116046.htm
DOI: https://dx.doi.org/10.5312/wjo.v17.i4.116046

Yu AX, Liang WH, Zhou YS, Li P, Ji JM, Zhang FW, Yu P, Liu J. Xianling Gubao capsule alleviates osteoporosis: Modulation of gut-bone axis and Wnt signaling. World J Orthop 2026; 17(4): 116046 [DOI: 10.5312/wjo.v17.i4.116046]

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