Xianling Gubao capsule alleviates osteoporosis: Modulation of gut-bone axis and Wnt signaling

doi:10.5312/wjo.v17.i4.116046

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World Journal of Orthopedics

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2218-5836

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Orthop. Apr 18, 2026; 17(4): 116046
Published online Apr 18, 2026. doi: 10.5312/wjo.v17.i4.116046

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Figure 7 Effects of Xianling Gubao capsule on intestinal microbiota composition and metabolic pathways in ovariectomized rats. A: Phylum-level composition abundance; B: Genus-level species composition abundance; C: Spearman correlation between the top 10 most abundant phyla and bone formation indicators; D: Spearman correlation between the top 15 most abundant genera and bone formation indicators. Data are presented as the mean ± SD (n = 5). ^aP < 0.05 vs ovariectomy group; ^bP < 0.01 vs ovariectomy group; ^cP < 0.001 vs ovariectomy group. Sham: Sham-operated; OVX: Ovariectomy; XLGB-M: Xianling Gubao capsule-middle; OCN: Osteocalcin; PINP: Procollagen I N-terminal propeptide; BMD: Bone mineral density; BV: Bone volume; TV: Tissue volume; E2: Estradiol; Ca: Calcium; ALP: Alkaline phosphatase; Tb.Th: Trabecular thickness; Tb.Sp: Trabecular separation; Tb.N: Trabecular number.

Citation: Yu AX, Liang WH, Zhou YS, Li P, Ji JM, Zhang FW, Yu P, Liu J. Xianling Gubao capsule alleviates osteoporosis: Modulation of gut-bone axis and Wnt signaling. World J Orthop 2026; 17(4): 116046
URL: https://www.wjgnet.com/2218-5836/full/v17/i4/116046.htm
DOI: https://dx.doi.org/10.5312/wjo.v17.i4.116046

Yu AX, Liang WH, Zhou YS, Li P, Ji JM, Zhang FW, Yu P, Liu J. Xianling Gubao capsule alleviates osteoporosis: Modulation of gut-bone axis and Wnt signaling. World J Orthop 2026; 17(4): 116046 [DOI: 10.5312/wjo.v17.i4.116046]

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