Xianling Gubao capsule alleviates osteoporosis: Modulation of gut-bone axis and Wnt signaling

Figure 3 Xianling Gubao capsule regulates serum levels of bone metabolism markers and minerals in ovariectomy rats. A: Serum level of procollagen I N-terminal propeptide; B: Serum level of collagen type I alpha 1; C: Serum level of osteocalcin; D: Serum level of runt-related transcription factor 2; E: Serum calcium concentration; F: Serum phosphorus concentration; G: Serum alkaline phosphatase activity. Data are presented as the mean ± SD (n = 10). ^bP < 0.01 vs ovariectomy group; ^cP < 0.001 vs ovariectomy group; ^dP < 0.05 vs sham-operated group; ^eP < 0.01 vs sham-operated group. Sham: Sham-operated; OVX: Ovariectomy; E2: Estradiol; XLGB-L: Xianling Gubao capsule-low; XLGB-M: Xianling Gubao capsule-middle; XLGB-H: Xianling Gubao capsule-high; PINP: Procollagen I N-terminal propeptide; COL1A1: Collagen type I alpha 1; OCN: Osteocalcin; RUNX2: Runt-related transcription factor 2; Ca: Calcium; P: Phosphorus; ALP: Alkaline phosphatase.