Xianling Gubao capsule alleviates osteoporosis: Modulation of gut-bone axis and Wnt signaling

doi:10.5312/wjo.v17.i4.116046

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World Journal of Orthopedics

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2218-5836

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Orthop. Apr 18, 2026; 17(4): 116046
Published online Apr 18, 2026. doi: 10.5312/wjo.v17.i4.116046

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Figure 2 Xianling Gubao capsule improves the bone microstructure in ovariectomy rats. A: Representative micro-computed tomography images of the distal femur (coronal view); B: Quantitative analysis of bone microstructural parameters, including bone mineral density, bone volume/tissue volume, trabecular separation, trabecular number, and trabecular thickness. Data are presented as the mean ± SD (n = 10). ^aP < 0.05 vs ovariectomy group; ^bP < 0.01 vs ovariectomy group; ^cP < 0.001 vs ovariectomy group; ^eP < 0.01 vs sham-operated group. Sham: Sham-operated; OVX: Ovariectomy; E2: Estradiol; XLGB-L: Xianling Gubao capsule-low; XLGB-M: Xianling Gubao capsule-middle; XLGB-H: Xianling Gubao capsule-high; BMD: Bone mineral density; BV: Bone volume; TV: Tissue volume; Tb.Sp: Trabecular separation; Tb.N: Trabecular number; Tb.Th: Trabecular thickness.

Citation: Yu AX, Liang WH, Zhou YS, Li P, Ji JM, Zhang FW, Yu P, Liu J. Xianling Gubao capsule alleviates osteoporosis: Modulation of gut-bone axis and Wnt signaling. World J Orthop 2026; 17(4): 116046
URL: https://www.wjgnet.com/2218-5836/full/v17/i4/116046.htm
DOI: https://dx.doi.org/10.5312/wjo.v17.i4.116046

Yu AX, Liang WH, Zhou YS, Li P, Ji JM, Zhang FW, Yu P, Liu J. Xianling Gubao capsule alleviates osteoporosis: Modulation of gut-bone axis and Wnt signaling. World J Orthop 2026; 17(4): 116046 [DOI: 10.5312/wjo.v17.i4.116046]

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