Machine learning identifies complement factor I as a shared mediator of periodontitis and ossification of posterior longitudinal ligament

Figure 5 Single-cell characterization of complement factor I expression and functional enrichment in periodontitis. A and B: Quality control of single cell data; C-E: Expression distribution of complement factor I (CFI) across different cell types; F and G: Identification of the primary cellular source of CFI; F: Proportion of each cell subset in CFI-positive and CFI-negative groups; G: Comparative analysis demonstrating endothelial cells as the dominant source of CFI expression; H: Cell trajectory analysis showing progressive increase of CFI expression during endothelial cell differentiation; I: Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis of differentially expressed genes in CFI-positive vs CFI-negative groups, highlighting significant enrichment in pathways related to cell adhesion, bacterial infection, and intracellular signaling.