Machine learning identifies complement factor I as a shared mediator of periodontitis and ossification of posterior longitudinal ligament

Figure 2 Identification of shared core genes between ossification of the posterior longitudinal ligament and periodontitis via weighted gene co-expression network analysis and meta-analysis. A: Schematic workflow of the study; B: Differential gene expression analysis in ossification of the posterior longitudinal ligament (OPLL); C-E: Identification of key modules by weighted gene co-expression network analysis; Gene clustering dendrogram (C); Module-trait relationships showing the “lightpink4” module with the strongest association to OPLL (D); Characteristic scatter plot of the “lightpink4” module (E); F: Information of the periodontitis transcriptomic datasets; G: Standardized mean difference analysis of 45 co-expressed genes demonstrating consistent differential expression in periodontitis. SMD: Standardized mean difference.