Musculoskeletal problems of people with hemophilia aged > 65 years

Table 1 Factor replacement schedule for people with hemophilia A or B aged > 65 years without inhibitors based on World Federation of Hemophilia guidelines

Type of surgery	Hemophilia A		Hemophilia B
	Aim peak levels (%)	Time span	Aim peak levels (%)	Time span
Minor orthopedic surgery	50-80	Day of surgery	50-80	Day of surgery
	30-80	Days 1-5	30-80	Days 1-5
Major orthopedic surgery	80-100	Day of surgery	60-80	Day of surgery
	60-80	Days 1-3	40-60	Days 1-3
	40-60	Days 4-6	30-50	Days 4-6
	30-50	Days 7-14	20-40	Days 7-14

Dosing must be individualized according to factor level monitoring, thrombotic risk and center protocols.