Integrating Mendelian randomization and enzyme-linked immunosorbent assay validation identifies candidate mediators across the rheumatoid arthritis disease continuum

Figure 4 Correlation analysis of serum inflammatory cytokine levels in 41 patients with rheumatoid arthritis and 41 healthy controls (n = 82). Pearson correlation coefficients showed significant positive correlations among all pairs (r = 0.436-0.609, all P < 0.0001). A: Correlation between CD40 and C-C motif chemokine ligand 28 (CCL28); B: Correlation between CD40 and matrix metalloproteinase-1 (MMP-1); C: Correlation between CCL28 and MMP-1; D: Correlation between CD40 and interleukin-18 receptor 1 (IL-18R1); E: Correlation between CCL28 and IL-18R1; F: Correlation between MMP-1 and IL-18R1. CI: Confidence interval.