Integrating Mendelian randomization and enzyme-linked immunosorbent assay validation identifies candidate mediators across the rheumatoid arthritis disease continuum

doi:10.5312/wjo.125433

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World Journal of Orthopedics

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2218-5836

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Orthop. Nov 18, 2026; 17(11): 125433
Published online Nov 18, 2026. doi: 10.5312/wjo.125433

Table 2 Baseline characteristics of the study population

Characteristics	RA group (n = 41)	Control group (n = 41)	P value
Sex, female	33 (80.49)	33 (80.49)	1.000
Age, years	56.20 ± 13.28	52.20 ± 10.33	0.132
BMI, kg/m²	22.41 ± 3.31	22.37 ± 2.92	0.346
Smoking status	5 (12.20)	4 (9.76)	1.000
Disease duration, months	6 (2, 8)	-	-
DAS28-ESR	5.20 ± 1.27	-	-

Data are presented as n (%), mean ± SD, or median (interquartile range).

BMI: Body mass index; DAS28-ESR: Disease Activity Score 28-joint count using erythrocyte sedimentation rate; RA: Rheumatoid arthritis.

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Citation: Song YS, Luo JL, Zheng XF, Chen YP, Li ZM, Yao J. Integrating Mendelian randomization and enzyme-linked immunosorbent assay validation identifies candidate mediators across the rheumatoid arthritis disease continuum. World J Orthop 2026; 17(11): 125433
URL: https://www.wjgnet.com/2218-5836/full/v17/i11/125433.htm
DOI: https://dx.doi.org/10.5312/wjo.125433

Song YS, Luo JL, Zheng XF, Chen YP, Li ZM, Yao J. Integrating Mendelian randomization and enzyme-linked immunosorbent assay validation identifies candidate mediators across the rheumatoid arthritis disease continuum. World J Orthop 2026; 17(11): 125433 [DOI: 10.5312/wjo.125433]

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