Single-cell RNA-sequencing analysis reveals cellular states and intercellular communication of human lumbar facet-joint degeneration

doi:10.5312/wjo.125372

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World Journal of Orthopedics

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2218-5836

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Orthop. Nov 18, 2026; 17(11): 125372
Published online Nov 18, 2026. doi: 10.5312/wjo.125372

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Figure 5 Distribution and trajectories of macrophage subpopulations during the degeneration process of human lumbar facet joint. A: Gene ontology functions of macrophage subpopulations. Number 1-5 represents Mφ-F13A1, Mφ-TCN2, Mφ-COL27A1, Mφ-CD52 and Mφ-IL3RA respectively; B: Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis of macrophage subpopulations; C: Distribution of macrophage subclusters in mild and severe degenerated lumbar facet joint cartilage samples; D: Representative immunohistochemistry staining of IL3RA of macrophage subclusters in different degenerated lumbar facet joint cartilage samples. Scale bar 100 μm; E: RNA velocity-based pseudotime analysis inferred from Uniform Manifold Approximation and Projection embedding of macrophage subclusters.

Citation: Chen XY, Luo W, Chen YZ, Wang L, Zhang YY, Li HY, Wang P, Man ZT, Li W, Wang DD. Single-cell RNA-sequencing analysis reveals cellular states and intercellular communication of human lumbar facet-joint degeneration. World J Orthop 2026; 17(11): 125372
URL: https://www.wjgnet.com/2218-5836/full/v17/i11/125372.htm
DOI: https://dx.doi.org/10.5312/wjo.125372

Chen XY, Luo W, Chen YZ, Wang L, Zhang YY, Li HY, Wang P, Man ZT, Li W, Wang DD. Single-cell RNA-sequencing analysis reveals cellular states and intercellular communication of human lumbar facet-joint degeneration. World J Orthop 2026; 17(11): 125372 [DOI: 10.5312/wjo.125372]

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