Single-cell RNA-sequencing analysis reveals cellular states and intercellular communication of human lumbar facet-joint degeneration

doi:10.5312/wjo.125372

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World Journal of Orthopedics

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2218-5836

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Orthop. Nov 18, 2026; 17(11): 125372
Published online Nov 18, 2026. doi: 10.5312/wjo.125372

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Figure 3 Distribution and trajectories of lumbar facet joint cartilage chondrocyte subpopulations during the degeneration process of human lumbar facet joint. A: Gene ontology functions of eight lumbar facet joint (LFJ) cartilage chondrocyte subpopulations; B: Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis of eight LFJ cartilage chondrocyte subpopulations; C: Distribution of chondrocyte subclusters in mild (FJ1) and severe (FJ2-3) degenerated LFJs; D: RNA velocity-based pseudotime analysis inferred from Uniform Manifold Approximation and Projection embedding of LFJ chondrocyte subclusters. ProCs: Proliferative chondrocytes; PreHTCs: Prehypertrophic chondrocytes; HTCs: Hypertrophic chondrocytes; FCs: Fibrocartilage chondrocytes; ECs: Effector chondrocytes.

Citation: Chen XY, Luo W, Chen YZ, Wang L, Zhang YY, Li HY, Wang P, Man ZT, Li W, Wang DD. Single-cell RNA-sequencing analysis reveals cellular states and intercellular communication of human lumbar facet-joint degeneration. World J Orthop 2026; 17(11): 125372
URL: https://www.wjgnet.com/2218-5836/full/v17/i11/125372.htm
DOI: https://dx.doi.org/10.5312/wjo.125372

Chen XY, Luo W, Chen YZ, Wang L, Zhang YY, Li HY, Wang P, Man ZT, Li W, Wang DD. Single-cell RNA-sequencing analysis reveals cellular states and intercellular communication of human lumbar facet-joint degeneration. World J Orthop 2026; 17(11): 125372 [DOI: 10.5312/wjo.125372]

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