Osthole exerts osteoprotective effect by activating ER, PI3K/AKT, MEK/ERK, and Wnt/β-catenin signaling pathways

doi:10.5312/wjo.121526

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World Journal of Orthopedics

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2218-5836

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Orthop. Oct 18, 2026; 17(10): 121526
Published online Oct 18, 2026. doi: 10.5312/wjo.121526

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Figure 7 Schematic diagram of the osteoprotective mechanism of osthole. Created with BioGDP.com. OPG: Osteoprotegerin; RANKL: Receptor activator of nuclear factor-κB ligand; ER: Estrogen receptor; ERK: Extracellular signal-regulated kinase; AKT: Protein kinase B.

Citation: Zhu TY, Yuan M, Wen XC, Tian CC, Han YH, Zheng C, Wu YT, Xia Q, Wang Y. Osthole exerts osteoprotective effect by activating ER, PI3K/AKT, MEK/ERK, and Wnt/β-catenin signaling pathways. World J Orthop 2026; 17(10): 121526
URL: https://www.wjgnet.com/2218-5836/full/v17/i10/121526.htm
DOI: https://dx.doi.org/10.5312/wjo.121526

Zhu TY, Yuan M, Wen XC, Tian CC, Han YH, Zheng C, Wu YT, Xia Q, Wang Y. Osthole exerts osteoprotective effect by activating ER, PI3K/AKT, MEK/ERK, and Wnt/β-catenin signaling pathways. World J Orthop 2026; 17(10): 121526 [DOI: 10.5312/wjo.121526]

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