Rethinking the role of bisphosphonates after denosumab treatment in locally advanced or unresectable aneurysmal bone cysts: A meta-analysis

doi:10.5312/wjo.v16.i8.107083

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Aug 18, 2025 (publication date) through Aug 11, 2025

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World Journal of Orthopedics

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2218-5836

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Meta-Analysis

World J Orthop. Aug 18, 2025; 16(8): 107083
Published online Aug 18, 2025. doi: 10.5312/wjo.v16.i8.107083

Table 3 Side effects during and after denosumab therapy, n (%)

Side effects	Frequency
Hypercalcemia	12 (29)
Hypercalcemia + Growth plate ossification	1 (2)
Hypocalcemia + Hypercalcemia	1 (2)
Hypocalcemia + Hypophosphatemia + Hypercalcemia	1 (2)
Hypocalcemia + Hypophosphatemia	1 (2)
Vomiting	1 (2)
Not reported	26 (60)
Total	43

Citation: Machak GN, Bruland ØS, Kovalev AV, Rodionova SS. Rethinking the role of bisphosphonates after denosumab treatment in locally advanced or unresectable aneurysmal bone cysts: A meta-analysis. World J Orthop 2025; 16(8): 107083
URL: https://www.wjgnet.com/2218-5836/full/v16/i8/107083.htm
DOI: https://dx.doi.org/10.5312/wjo.v16.i8.107083