Intertwined roles of microRNA-155 and metformin in osteoarthritis: Novel potential diagnostic, prognostic, and therapeutic modulators

Table 1 Transcription factors binding sites in the MIR155HG gene

Number of MIR155HG transcription binding sites
Three (3) sites	Two (2) sites	One (1) site	Oncology-associated
Hypoxia-inducible factor-1 alpha	Nuclear factor kappa-B, forkhead box protein P3 (associated with oncogene special AT-rich binding protein-1), ETS proto-oncogene 1	RNA Polymerase II Subunit A, mothers against decapentaplegic homolog 4, interferon-sensitive response element, interferon regulatory factors, Activator protein 1, CCAAT/enhancer-binding protein alpha), ETS family member ELK3	DNA promoter methylation and transcription factor (SP1), v-myb myeloblastosis viral oncogene homolog, Annexin A2, breast cancer 1, early onset

ETS: Erythroblast transformation-specific.