Nanotechnology for pain management in orthopedic surgery

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World Journal of Orthopedics

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2218-5836

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Orthop. Oct 18, 2025; 16(10): 110009
Published online Oct 18, 2025. doi: 10.5312/wjo.v16.i10.110009

Table 2 Contraindications to the use of Zynrelef^®

Contraindications
Individuals with proven hypersensitivity to local anesthetics and NSAIDs
Individuals with a history of asthma, urticaria, or allergic reaction related to aspirin or other NSAIDs
Individuals receiving obstetric paracervical block anesthesia
Individuals experiencing coronary bypass surgery

NSAIDs: Non-steroidal anti-inflammatory drugs.

Citation: Rodriguez-Merchan EC, De Andres-Ares J, Delgado-Martinez AD, Ribbans WJ. Nanotechnology for pain management in orthopedic surgery. World J Orthop 2025; 16(10): 110009
URL: https://www.wjgnet.com/2218-5836/full/v16/i10/110009.htm
DOI: https://dx.doi.org/10.5312/wjo.v16.i10.110009

Rodriguez-Merchan EC, De Andres-Ares J, Delgado-Martinez AD, Ribbans WJ. Nanotechnology for pain management in orthopedic surgery. World J Orthop 2025; 16(10): 110009 [PMID: 41181047 DOI: 10.5312/wjo.v16.i10.110009]

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