Nanotechnology for pain management in orthopedic surgery

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Publication Name

World Journal of Orthopedics

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2218-5836

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Orthop. Oct 18, 2025; 16(10): 110009
Published online Oct 18, 2025. doi: 10.5312/wjo.v16.i10.110009

Table 1 Benefits of multivesicular particles (DepoFoam bupivacaine^®) based medications

Benefits
High drug-loading capacity combined with controlled release, resulting in enhanced analgesic efficacy
Uniform and lengthy medication liberation
Increased encapsulation yield
Structural stability
Inferior exposure and toxicity in another location
Negligible negative complications
Greater medication half-life
Biocompatibility for medication liberation into frail zones (e.g. epidural, intrathecal)

Citation: Rodriguez-Merchan EC, De Andres-Ares J, Delgado-Martinez AD, Ribbans WJ. Nanotechnology for pain management in orthopedic surgery. World J Orthop 2025; 16(10): 110009
URL: https://www.wjgnet.com/2218-5836/full/v16/i10/110009.htm
DOI: https://dx.doi.org/10.5312/wjo.v16.i10.110009

Rodriguez-Merchan EC, De Andres-Ares J, Delgado-Martinez AD, Ribbans WJ. Nanotechnology for pain management in orthopedic surgery. World J Orthop 2025; 16(10): 110009 [PMID: 41181047 DOI: 10.5312/wjo.v16.i10.110009]

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