Early diagnosis and targeted intervention based on the pathogenesis of rapidly progressive osteoarthritis of the hip

Figure 6 Putative pathophysiology at the initial stage of rapidly progressive osteoarthritis of the hip. DAMP: Danger-associated molecular pattern; TLR: Toll-like receptor; NF-κB: Nuclear factor κB; NLRP3: Nucleotide-binding and oligomerization domain-like receptor family pyrin domain containing 3; GSDMD: Gasdermin D; GSDMD-NT: N-terminal pore-forming gasdermin D fragment; IL: Interleukin; TNF-α: Tumor necrosis factor α; JAK: Janus kinase; STAT3: Signal transducer and activator of transcription 3; MAPK: Mitogen-activated protein kinase; MMPs: Matrix metalloproteinases; RANKL: Receptor activator of nuclear factor-κB ligand; RPOH: Rapidly progressive osteoarthritis of the hip.