Long-term assessment of collagenase treatment for Dupuytren’s contracture: A 10-year follow-up study

Table 1 Inclusion and exclusion criteria of the prospective study

Inclusion criteria	Exclusion criteria
DC with a PED of at least 20° at MCPJ and any degree at PIPJ	Breastfeeding or pregnant (or planning to be) during the treatment phase
No oral anticoagulant therapy; patient in therapy with anti-platelet drugs (discontinued for at least 7 d before treatment)	Undergoing any treatment of the affected hand up to 90 d prior to commencement of the trial
Positive table-top test (a patient fails to lay the palm of the hand and the fingers flat on a table surface)	Known systemic hypersensitivity to collagenase or any of the other components of the product
TPED ≥ 45° (that is greater than or equal to the second stage according to the Tubiana-Michon classification)	Presence of other psychiatric or organic conditions that could jeopardize the patient’s compliance
Palpable cord
Informed consent from the patient
Consent for examination according to the plan

DC: Dupuytren’s contracture; PED: Passive extension deficit; MCPJ: Metacarpophalangeal joint; PIPJ: Proximal interphalangeal joint; TPED: Total passive extension deficit.