Diagnosis and treatment of chronic osteomyelitis based on nanomaterials

Figure 3 The illustration of APGH released the Aptamer-functionalized platinum nanozymes and glucose oxidase and its application for chemodynamic sterilization. A: The preparation route for the nanozyme capsule (APGH) with aptamer-functionalized platinum nanozymes, glucose oxidase and hyaluronic acid; B: Schematic illustration of APGH activation, activity switching in the infected wound, and its application for chemodynamic sterilization through in situ generation of COH on bacteria surface. Apt-PtNZ: Aptamer-functionalized platinum nanozymes; HA: Hyaluronic acid; GOX: Glucose oxidase. Citation: Chen L, Xing S, Lei Y, Chen Q, Zou Z, Quan K, Qing Z, Liu J, Yang R. A Glucose-Powered Activatable Nanozyme Breaking pH and H₂O₂ Limitations for Treating Diabetic Infections. Angew Chem Int Ed Engl 2021; 60: 23534-23539. Copyright ©The Author(s) 2021. Published by John Wiley and Sons. The authors have obtained the permission for figure using from the John Wiley and Sons and Copyright Clearance Center (Supplementary material).