Single- and double-dose of platelet-rich plasma versus hyaluronic acid for treatment of knee osteoarthritis: A randomized controlled trial

Table 3 Comparison of mean scores and percentage change in each parameter of the Western Ontario and McMaster Universities Arthritis Index and Visual Analog Scale with baseline at each follow-up for the three groups

	Follow-up
Variable-s	0	Wk 4	Wk 8	Wk 12	0	Wk 4	Wk 8	Wk 12	0	Wk 4	Wk 8	Wk 12
	Group PRP-1 (Single injection; n = 28 patients)				Group PRP-2 (Double injection; n = 28 patients)				Group hyaluronic acid (n = 27 patients)
WOMAC subscales
Pain
Mean	12.03	6.11	6.46	7.32	12.11	5	5.29	6.25	12.07	9.41	9.67	10.63
P value	Mean scores decreased significantly (P < 0.05)				Mean scores decreased significantly (P < 0.05)				Mean scores decreased significantly (P < 0.05)
% change1 (vs baseline)		-49.09	-45.81	-39.09		-59.47	-56.95	-48.61		-22.01	-19.80	-11.34
P value	At each follow-up, the percentage change from baseline was greater in group PRP-2 than in group PRP-1, and greater in group PRP-1 than in group hyaluronic acid (P < 0.001).
Stiffness
Mean	4.39	2.14	2.25	2.79	5.04	1.75	1.89	2.57	4.85	3.11	3.07	3.93
P value	Mean scores decreased significantly (P < 0.05)				Mean scores decreased significantly (P < 0.05)				Mean scores decreased significantly (P < 0.05)
% change1 (vs baseline)		-50.64	-47.36	-32.87		-67.96	-65.12	-47.65		-32.50	-33.16	-14.42
P value	At each follow-up, the percentage change from baseline was greater in group PRP-2 than in group PRP-1, and greater in group PRP-1 than in group hyaluronic acid (P < 0.001).
Physical function
Mean	46.93	28.14	28.04	31.89	44.39	22	23.39	26.54	46.19	37.85	39.41	42.52
P value	Mean scores decreased significantly (P < 0.05)				Mean scores decreased significantly (P < 0.05)				Mean scores decreased significantly (P < 0.05)
% change1 (vs baseline)		-39.28	-39.30	-30.97		-49.46	-46.31	-38.91		-18.31	-14.53	-7.69
P value	At each follow-up, the percentage change from baseline was greater in group PRP-2 than in group PRP-1, and greater in group PRP-1 than in group hyaluronic acid (P < 0.001).
Total
Mean	63.71	36.46	37.14	42.5	61.57	28.75	30.61	35.32	63.11	50.44	52.67	57.26
P value	Mean scores decreased significantly (P < 0.05)				Mean scores decreased significantly (P < 0.05)				Mean scores decreased significantly (P < 0.05)
% change1 (vs baseline)		-42.34	-41.13	-32.66		-52.77	-49.79	-41.75		-20.35	-16.61	-9.12
P value	At each follow-up, the percentage change from baseline was greater in group PRP-2 than in group PRP-1, and greater in group PRP-1 than in group hyaluronic acid (P < 0.001).
VAS
Mean	8.25	4.32	4.61	5.39	8.29	2.89	3.79	4.46	8.15	5.96	6.37	7.04
P value	Mean scores decreased significantly (P < 0.05)				Mean scores decreased significantly (P < 0.05)				Mean scores decreased significantly (P < 0.05)
% change1 (vs baseline)		-47.6	-44.25	-34.44		-65.28	-54.31	-46.25		-26.69	-21.99	-13.71
P value	At each follow-up, the percentage change from baseline was greater in group PRP-2 than in group PRP-1, and greater in group PRP-1 than in group hyaluronic acid (P < 0.001).

¹Negative percent shows improvement from baseline. VAS: Visual analog scale; WOMAC: Western Ontario and McMaster Universities Arthritis Index.