Single- and double-dose of platelet-rich plasma versus hyaluronic acid for treatment of knee osteoarthritis: A randomized controlled trial

doi:10.5312/wjo.v10.i9.310

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World Journal of Orthopedics

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Randomized Controlled Trial

World J Orthop. Sep 18, 2019; 10(9): 310-326
Published online Sep 18, 2019. doi: 10.5312/wjo.v10.i9.310

Table 2 Number of patients having at least a 30% and 50% decrease in the summed score for the Western Ontario and McMaster Universities Arthritis Index and Visual Analog Scale, n (%)

	Follow-up
Variables	1^st (wk 4)	2^nd (wk 8)	3^rd (wk 12)	1^st (wk 4)	2^nd (wk 8)	3^rd (wk 12)	1^st (wk 4)	2^nd (wk 8)	3^rd (wk 12)
Variables	Group PRP-1 (Single injection; n = 28 patients)			Group PRP-2 (Double injection; n = 28 patients)			Group hyaluronic acid (n = 27 patients)
	Patients having at least a 30% decrease in the summed score for the scales
WOMAC pain score	28 (100)	27 (96.4)	24 (85.7)	28 (100)	28 (100)	28 (100)	6 (22.2)	5 (18.5)	0 (0)
P value¹	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	-	-	-
WOMAC stiffness score	26 (92.9)	25 (89.3)	19 (67.9)	28 (100)	28 (100)	25 (89.3)	16 (59.3)	17 (63)	5 (18.5)
P value¹	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	-	-	-
WOMAC physical function score	26 (92.9)	23 (82.1)	12 (42.9)	28 (100)	26 (92.9)	23 (82.1)	2 (7.4)	0 (0)	0 (0)
P value¹	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	-	-	-
Total WOMAC score	27 (96.4)	26 (92.9)	17 (60.7)	28 (100)	28 (100)	24 (85.7)	2 (7.4)	0 (0)	0 (0)
P value¹	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	-	-	-
	Patients having at least a 50% decrease in the summed score for the scales
WOMAC pain score	14 (50)	11 (39.3)	6 (21.4)	25 (89.3)	23 (82.1)	16 (19.3)	0 (0)	0 (0)	0 (0)
P value¹	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	-	-	-
WOMAC stiffness score	17 (60.7)	16 (57.1)	7 (25)	26 (92.9)	26 (92.9)	16 (57.1)	8 (29.6)	8 (29.6)	1 (3.7)
P value¹	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	-	-	-
WOMAC physical function score	5 (17.9)	5 (17.9)	1 (3.6)	17 (60.7)	11 (39.3)	5 (17.9)	0 (0)	0 (0)	0 (0)
P value¹	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	-	-	-
Total WOMAC score	6 (21.4)	5 (17.9)	0 (0)	19 (67.9)	17 (60.7)	7 (25)	0 (0)	0 (0)	0 (0)
P value¹	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	-	-	-
VAS pain score	17 (60.7)	11 (39.3)	2 (7.1)	28 (100)	25 (89.3)	17 (60.7)	3 (11.1)	2 (7.4)	0 (0)
P value¹	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	-	-	-

¹In comparison with hyaluronic acid group. VAS: Visual analog scale; WOMAC: Western Ontario and McMaster Universities Arthritis Index.

Citation: Tavassoli M, Janmohammadi N, Hosseini A, Khafri S, Esmaeilnejad-Ganji SM. Single- and double-dose of platelet-rich plasma versus hyaluronic acid for treatment of knee osteoarthritis: A randomized controlled trial. World J Orthop 2019; 10(9): 310-326
URL: https://www.wjgnet.com/2218-5836/full/v10/i9/310.htm
DOI: https://dx.doi.org/10.5312/wjo.v10.i9.310