Single- and double-dose of platelet-rich plasma versus hyaluronic acid for treatment of knee osteoarthritis: A randomized controlled trial

Table 1 Comparison of baseline characteristics of the patients in the three groups

Variables	Group PRP-1 (Single injection; n = 28 patients)	Group PRP-2 (Double injection; n = 28 patients)	Group hyaluronic acid (n = 27 patients)	P value
Gender, M/F, n	5/23	6/22	8/19	0.323
Age, mean ± SD, yr-old	63.23 ± 8.03	66.04 ± 7.58	63.30 ± 8.87	0.121
Weight, mean ± SD, kg	73.36 ± 7.02	76.57 ± 6.58	75.37 ± 8.10	0.252
Height, mean ± SD, cm	160.57 ± 7.25	160.43 ± 6.57	159.37 ± 17.27	0.504
BMI, mean ± SD, kg/m2	28.43 ± 2.11	29.61 ± 1.64	28.94 ± 2.26	0.097
Ahlback grade, n	(n = 56 knees)	(n = 56 knees)	(n = 54 knees)	0.509
1	21	17	22
2	35	39	32
WOMAC score, mean ± SD	(n = 56 knees)	(n = 56 knees)	(n = 54 knees)
Pain	12.03 ± 2.31	12.11 ± 2.53	12.07 ± 2.41	0.958
Stiffness	4.39 ± 1.53	5.04 ± 2.01	4.85 ± 1.84	0.077
Physical function	46.93 ± 7.59	44.39 ± 7.82	46.19 ± 6.32	0.236
Total	63.71 ± 9.87	61.57 ± 11.29	63.11 ± 8.94	0.695
VAS score, mean ± SD	8.25 ± 0.92	8.29 ± 0.80	8.15 ± 0.81	0.631

BMI: Body mass index; F: Female; M: Male; PRP: Platelet-rich plasma; VAS: Visual analog scale; WOMAC: Western Ontario and McMaster Universities Arthritis Index.