Bone fragility in type 2 diabetes mellitus

Table 1 Odds ratio of surrogate markers for the presence of prevalent vertebral fractures

	Presence of vertebral fractures
	OR (95% CI)	P
Pentosidine (male)	0.79 (0.41-1.52)	0.47
Pentosidine (female)	2.50 (1.09-5.73)	0.03
esRAGE (male)	0.46 (0.25-0.84)	0.012
esRAGE (female)	0.32 (0.16-0.67)	0.002
IGF-I (female)	0.44 (0.23-0.81)	0.009

Multivariate logistic regression analysis was performed with the presence of vertebral fractures as a dependent variable and each of levels of serum insulin-like growth factor (IGF)-I, C-peptide, osteocalcin, and uNTX adjusted for age, duration of diabetes, body weight, height, creatinine, albumin, and HbA1c as independent variables. esRAGE: Endogenous secretory receptor for advanced glycation end product; OR: Odds ratio; CI: Confidence interval.