Histone deacetylases, microRNA and leptin crosstalk in pancreatic cancer

Table 1 Classification of classical histone deacetylases

Class	Members	Cellular localization	Function in cancer[13,14,45,46,104]	Substrates[43,44,104]
I	HDAC1	Nucleus	Proliferation, survival and resistance to chemoresistance	P53, E2F-1, Stat3, and androgen
	HDAC2	Nucleus	Proliferation and survival	Bcl-6, Stat3. YY-1, and glucocorticoid receptor
	HDAC3	Nucleus	Proliferation and anti-differentiation	GATA-1, RelA, Stat3, MEF2D, YY-1, and SHP
	HDAC8	Nucleus	Proliferation and anti-differentiation	ERRα, Inv (16), and CREB
IIA	HDAC4	Nucleus/cytoplasm	Angiogenesis and anti-differentiation	GCMa, GATA-1, and HP-1
	HDAC5	Nucleus/cytoplasm	Anti-differentiation	Smad7, HP-1, and GCMa
	HDAC7	Nucleus/cytoplasm	Angiogenesis and migration	FLAG-1, and FLAG-2
	HDAC9	Nucleus/cytoplasm	Cell survival	ATDC (TRIM29)
IIB	HDAC6	Cytoplasm	Angiogenesis and migration	Alpha-Tubulin, HSP-90, SHP, Smad7
	HDAC10	Cytoplasm	Angiogenesis	HSP90
IV	HDAC11	Nucleus/cytoplasm	Tumor immune response	OX40L

HDAC: Histone deacetylases.