Nanoparticle-linked antagonist for leptin signaling inhibition in breast cancer

Figure 6 The effect of chemotherapeutics on survival of breast cancer cell lines. The effective dose of the chemotherapeutics. A: Cisplatin (Cis); B: Cyclophosphamide (CTX); C: Doxorubicin (Dox); D: Paclitaxel (PTX) were determined in MDA-MB-231, HCC1806, and MCF-7 cells. The cells were seeded in 6 well plates and treated with Cis (0.001-1.1 μmol/L), CTX (0.01-100 μmol/L), Dox (0.01-50 μmol/L), and PTX (0.05-1.0 μmol/L) for 1-6 d. Percent survival was determined by the Annexin V/FITC and PI assay. The relative survival was determined by multiplying the percentage of live cells by the total cell count.