Multiple roles of angiotensin in colorectal cancer

Figure 1 Aniotensinogen is activated to become a bioactive form, angiotensin II by some enzymes, such as ACE. In angiotensin receptors (blue boxed), angiotensin II type 1 receptor is pro-tumoral; however, angiotensin II type 2 receptor is not definitive. Angiotensin 1-7, a degraded product of angiotensin IIactivates MAS1 receptor to provide inhibitory effects. Substances marked with yellow boxes are possible inhibitors for angiotensin effects.