Intermittent fasting enhances cancer therapy via autophagy-dependent and independent mechanisms: Evidence and implications

Figure 2 Proposed model for intermittent fasting -induced autophagy upregulation in cancer prevention and therapy. In experimental cancer models, intermittent fasting-induced autophagy acts as a cellular stressor that enhances differential stress resistance during chemotherapy, protecting normal cells while promoting selective cancer cell death and increasing the efficacy of specific chemotherapeutic agents. Several forms of intermittent fasting-associated, autophagy-mediated cancer cell death have been documented[53-56]. DSR: Differential stress resistance.